105EVALUATION OF THE BIOCHEMICAL PARAMETERS OF APIGENIN IN FREUND’S COMPLETE ADJUVANT INDUCED ARTHRITIS IN WISTAR RATSThe current study was to evaluate the effect of apigenin, a non-mutagenic dietary flavonoid which was known to have antioxidant and anti-tumor properties in freund‟s complete adjuvant induced arthritis in wistar rats by analyzing its biochemical parameters. The study was performed on wistar rats of either sex weighing 180-200 gms. Experimental Arthritis was induced by injecting 0.1 ml of 5% of freund‟s complete adjuvant into the tibio tarsal joint of the left hind paw intraarticularly. Apigenin was given at a dose of 50mg/kg and 100mg/kg body weight for 28 days. Blood sample was collected on days 1, 7, 14, 21 and 28 for Erythrocyte Sedementation Rate (mm), Serum C- Reactive Protein (mg/l) and Rheumatoid factor (IU/ml) estimation by intraocular puncture. The results showed marked reduction in biochemical parameters in arthritis induced rats by apigenin at a dose of 100mg/kg which was comparable to the reference standard group treated with dexamethasone.vijaisundar@gmail.comResearch532015Apigenin,Arthritis,Wistar ratsE Vijai Sundar,Vanitha Samuel,Beyaril Chitra C,Predeep Kumar VAssistant Professor, Department of pharmacology, Tirunelveli medical college, Palayamkottai, Tirunelveli, Tamilnadu, India,Professor, Department of pharmacology, RMMC&H, Annamalai University, Chidambaram, Tamilnadu, India.,Assistant Professor, Department of pathology, Kanyakumari Government medical college, Kanyakumari, Tamilnadu, India.,Clinical pharmacologist, Apollo Hospital, Chennai, Tamilnadu, India.