109A STUDY ON COMPARISON OF THE EFFICACY OF ASENAPINE WITH THAT OF OLANZAPINEThe lack of efficacy and intolerance in patients with schizophrenia for the older, conventional antipsychotics, commonly defined as ―first-generation‖ antipsychotics, resulted in the introduction of second generation drugs. Hence this study carried out to compare the efficacy of Asenapine and Olanzapine. The present study was a prospective, open labeled, randomized controlled study conducted in VIMS, Bellary in 100 patients of schizophrenia. Patients were divided randomly into two groups of 50 patients each, with one group receiving Tab. Asenapine (5-10 mg/day) and the other group, Tab. Olanzapine (5-15 mg/day) for 6 weeks. Efficacy was assessed by using PANSS scale. The mean reductions in PANSS score at the end of the study (6 weeks) did not show any significant difference between the two groups.ramspsm@gmail.comResearch542015Efficacy,Asenapine,OlanzapineLakshmipathi BS,K.Lakshminarayana,Subramanya BKTutor, Department of Pharmacology, KIMS, Koppal, Karnataka, India,Professor & HOD, Department of Pharmacology, VIMS, Ballari, Karnataka, India.,Associate Professor, Department of Pharmacology, KIMS, Koppal, Karnataka, India