116EVALUTION OF HEPATOPROTECTIVE EFFECT OF CALOTROPIS GIGANTEA ROOT EXTRACT AGAINST ISONIAZIDE INDUCED HEPATOTOXICITYThis study aims to assess the protective effect of Calotropis gigantea extracts on experimentally drug induced hepatotoxicity in rats and to give a scientific rational for its folklore use. Rats were divided into five different groups each having six. Hepatotoxicity was induced by oral administration of 100mg/kg isoniazid for 30 days which significantly p<0.01 elevated the serum levels of biochemical markers like SGPT, SGOT, ALP, Bilirubin, Protein and depleted antioxidant enzymes catalase, GSHand SOD. Administration of Calotropis gigantea extract significantly prevented the alteration of isoniazide induced biochemical and antioxidant enzyme parameters. The effect of extract was compared with a standard drug, Silymarin which shows the similar results as it.The changes in biochemical parameters were furthur supported by histolopathological studies which shows protection against hyperplasia of epithelium hepatocyte degeneration caused by isoniazide. Hepatoprotective activity of the study plant may be attributed to the anti-oxidant principles present in it.vijaykiran.m93@gmail.comResearch542015Calotropis gigantea,Isoniazid,Hepatotoxicity,Oxidative stressM.Vijay Kiran, A.Swetha Sree,S.tripathy, K.SrinivasSri Vasavi Institute of Pharmaceutical Sciences, Tadepalligudem - 534101, West Godavari, Andhra Pradesh, India.,Sri Vasavi Institute of Pharmaceutical Sciences, Tadepalligudem - 534101, West Godavari, Andhra Pradesh, India.,Sri Vasavi Institute of Pharmaceutical Sciences, Tadepalligudem - 534101, West Godavari, Andhra Pradesh, India.,Sri Vasavi Institute of Pharmaceutical Sciences, Tadepalligudem - 534101, West Godavari, Andhra Pradesh, India.