110ADVERSE DRUG REACTIONS IN HOSPITALIZED CHILDREN IN A REFERRAL CENTRE IN KERALATo determine the characteristics of adverse drug reactions (ADRs) in hospitalized children of a tertiary care centre. A prospective study was done involving 5003 paediatric patients over a period of six months admitted to the children’s hospital in 2007. This study involved active surveillance in the form of daily visits to the wards. Data were entered in a structured proforma and analysed using SPSS version16. 99 patients (1.97%) developed ADRs. Maximum number of ADRs were secondary to anti-infective agents (53%) followed by anti-epileptic drugs (18%). The most commonly affected organ system involved was skin and appendages (58%). The study showed a male preponderance (68%) and the age group 0-1yrs was the most commonly involved (17.17%). 3% of ADRs patients gave a positive family history and a positive history of previous ADRs. The incidence of ADR is 1.97% with a male preponderance. The commonest class of drugs implicated are anti-infective agents of which the most common was penicillin. Poly-pharmacy is implicated in children treated with antiepileptic drugs. The frequency of ADRs was maximum in the age group 0-1year. The proportion of patients who were admitted with ADR was 52% and those who developed ADR after admission was 48%.drleo21@gmail.comResearch542015Adverse drug reactions,hospitalized children,KeralaSai Nathan R,Reneega GangadharAssistant Professor, Department of Pharmacology, Govt TDMC, Alappuzha, Kearala, India, Professor, Department of Pharmacology, Sree Mookambika Institute of Medical Sciences, Kulashekaram, Tamilnadu