112HOW EFFECTIVE ARE DIFFERENT INSULIN REGIMES TO MANAGE PERIOPERATIVE GLYCEMIC CONTROL IN TYPE 2 DIABETIC PATIENTS: AN OPEN RANDOMIZED TREAT-TO-TARGET STUDYIndia leads the world with the highest number of people suffering from Diabetes mellitus (DM). Also diabetics are more prone to surgery and its complications as compared to their non-diabetic counterparts. The study compares three different regimes of insulin for their efficacy, complications and cost-effectiveness, most commonly used to manage DM in perioperative period. These regimes are combination of shorter acting and longer acting analogues in Pre mixed and Split mixed forms. Total 171 diabetic patients admitted in SMS Hospital, Jaipur for some major elective surgery were enrolled into the study. On randomization they were divided into three groups receiving Regime A, B and C respectively. Regime A was Premixed Regular and NPH (R+NPH premixed) in ratio 30:70,Regime B was Split mixed Regular and NPH (R+NPH split mixed) and Regime C was Regular and Glargine (R+Glargine split mixed). When compared statistically it was observed that the group of patients who received longer acting Glargine showed better basal control of blood sugar with lesser complications and it was also better in terms of cost effectiveness than NPH given both in premixed and split mixed form.alkabansal04@gmail.comResearch542015Insulin,Surgery,PerioperativeAlka Bansal,Shivankan Kakkar,Monika MishraAssistant Professor,Department of Pharmacology, SMS Medical College, Jaipur, Rajasthan, India.,Senior Demonstrator, Department of Pharmacology, SMS Medical College, Jaipur, Rajasthan, India.,Professor, Department of Pharmacology, SMS Medical College, Jaipur, Rajasthan, India.