126SCREENING OF THE ADVERSE EFFECTS OF SUBSTANCES OF ABUSE ON KIDNEY FUNCTIONS: AN EGYPTIAN SINGLE CENTER STUDYRecently, substance abuse has become an increasingly prevalent problem all over the world. The kidneys - As an excretory organs- are highly vulnerable to the toxic effect of abuse substances. This study was aiming to study the nephrotoxic effect of commonly abused substances in Egypt on the kidney functions among abusers. In this study we have investigated the effects of commonly abused drugs in Egypt (tramadol, cannabis, opiates, barbiturates and benzodiazepines)on kidney functions (serum creatinine and blood urea nitrogen [BUN]).One Hundred - eighty four persons were screened for these substances using enzyme multiplied immunoassay technique (EMIT), positive samples were further confirmed by gas chromatography-mass spectroscopy (GC- MS). Eighty-nine cases showed positive results by GC-MS. Tramadol was the most commonly abused substance in the studied population (29 cases). Our data showed that substance abuse significantly increased level of serum creatinine and BUN among abusers (The mean level of serum creatinine level was statistically higher in abusers (1.08±0.4mg/dl) compared with non- abusers (0.85±0.25 mg/dl), this difference was statistically significant (P=0.0002).Thirty-seven abusers showed serum creatnine level ≥1.2 mg/dl. The mean level of BUN was also statistically higher in abusers (13.45±3mg/dl) compared with non- abusers (11.7±2.5 mg/dl) compared with non- abusers (11.7±2.5 mg/dl), again the difference was statistically significant (p=0.0007).Tramadol and other opioids were shown to be the most toxic to the kidneys. Kidney injury marker 1 (KIM1) and albumin/creatinine ratio (ACR) showed that tramadol renal injury is mainly tubular, while other opiates produce tubular and glomerular adverse effect. Substance abuse- especially tramadol and other opioids - significantly impairs the kidney function in healthy abusers, so they should be considered as a risk factor for renal injuryekramyelmorsy@mans.edu.egReview612016Tramadol, Substance abuse,KIM1,Albumin/createnine ratioEkramy Elmorsy,Mostafa Abdelsalam, Ahmed Mohammed Abd El-Whab,EmadFekry,AmalMisbah Elsaid,AlaaSabry,Maysaa El Sayed Zaki, Nahla AnberDepartment of Forensic Medicine and Clinical Toxicology, Mansoura faculty of Medicine, Egypt.,Department of Internal medicine, Mansoura Nephrology and Dialysis Unit, Faculty of Medicine, Mansoura University, Egypt.,Department of Internal medicine, Mansoura Nephrology and Dialysis Unit, Faculty of Medicine, Mansoura University, Egypt.,Department of Forensic Medicine and Clinical Toxicology, Mansoura faculty of Medicine, Egypt.,Clinical Pathology, Mansoura Chest Hospital, Ministry of Health,,Department of Internal medicine, Mansoura Nephrology and Dialysis Unit, Faculty of Medicine, Mansoura University, Egypt.Mansoura faculty of Medicine, Egypt.,Clinical Pathology Department, Mansoura faculty of Medicine, Egypt., Emergency Hospital, Mansoura faculty of Medicine, Egypt