127TOLERABILITY AND SAFETY PROFILE OF ENALAPRIL AND TELMISARTANEpidemiological studies show that there are significant geographical differences in occurrence of arterial hypertension and both between and within countries. Newer studies indicate that Telmisartan is efficacious throughout 24 hours Blood pressure control and better tolerability. Hundred (100) Patients were screened by subjecting them to required investigations before taking them into study. Safety profile was assessed by comparing the adverse effects in the patients of both groups with a standard adverse check list prepared, based on previous literature, for the study. The tolerability of antihypertensive was assessed by calculating the number of adverse effects experienced by the patients. In Enalapril group, 22(44%) patients showed adverse effects and 28(56%) patients did not show any adverse effects.In Telmisartan group, 4(8%) patients showed adverse effects and 46(92%) patients did not show any adverse effects. The unique and novel pharmacodynamic properties of Telmisartan make it asafer antihypertensive. Sharanappa2011gowda@gmail.comResearch612016Enalapril,Telmisartan,Tolerability,SafetySharanappa,Y.Vishwanath,Shyamala G,Swathi AcharyResident, Koppal Institute of Medical Sciences, Karnataka, India, Professor, Department of Pharmacology, VIMS, Ballari, Karnataka, India.,Professor, Department of Medicine, VIMS, Ballari, Karnataka, India., Assistant Professor, Department of Pharmacology, K.S Hegde Medical College Karnataka, India.