136DEVELOPMENT OF BIOSIMILARS: AN OVERVIEWThe use of biotechnology to develop medicines is rapidly growing as they provide effective, targeted treatment for many life threatening and chronic diseases in therapeutic areas like oncology, immunology, rheumatology, diabetes and inherited conditions. Biosimilars are biological products manufactured after expiry of the patent of innovator biopharmaceuticals. As the patents of a growing number of biologic medicines are due to expire, there is an increased interest in the development of biosimilars. They are larger and more complex molecules to manufacture. So, minor changes in manufacturing process can cause significant changes in efficacy and safety of the product. The quality comparison between biosimilars and innovator product is crucial and performed in every step to demonstrate biosimilarity drgujjarla@gmail.comReview612016Biologics,BiosimilarsHima Bindu GujjarlamudiAssistant Professor, Dept. of Pharmacology, Rajiv Gandhi Institute of Medical Sciences (RIMS), Ongole, Andhra Pradesh, India.