158STUDY AND EVALUATION OF MUCOADHESIVE BUCCAL TABLETS OF ONDANSETRON HYDROCHLORIDEThe tablets were prepared by wet granulation method using a combination of Mucoadhesive polymers like Chitosan, Ethyl Cellulose, HPMC and Sodium Alginate in different ratios. Buccal tablets were evaluated by different methods for parameters such as thickness, hardness, in-vitro drug release, ex-vivo drug permeation, etc. The tablets were evaluated for invitro release in pH 6.8 phosphate buffer for 12 hr. In order to determine the mode of release, the data was subjected to Zero order, first order, Higuchi and Peppas diffusion model. Sodium Alginate showed maximum mucoadhesion and required maximum force for detachment; the force required for detachment was directly proportional to its content. IR spectroscopic studies indicated that there are no drug-excipient interactions. The prepared buccal tablets of ODH could stay in the buccal for a longer period of time.dratiqurrahman@gmail.comResearch642016Mucoadhesive buccal tablet, Sodium Alginate,HPMC K4M,Chitosan,Mucoadhesive strength,exvivo drug permeationSyed Atiq-ur Rahman, Syed Arshaduddin AhmedDepartment of Pharmacology, Osmania Medical College, Hyderabad, Telangana, India.,Department of Pharmacology, Osmania Medical College, Hyderabad, Telangana, India.