151TO COMPARE THE EFFICACY, TOLERABILITY AND SAFETY PROFILE OF ASENAPINE, A NOVEL, SUBLINGUAL, ATYPICAL ANTIPSYCHOTIC WITH OLANZAPINE, A THIENOBENZODIAZEPINE ATYPICAL ANTIPSYCHOTICThe lack of efficacy and intolerance in patients with schizophrenia for the older, conventional antipsychotics, commonly defined as “first-generation” antipsychotics, resulted in the introduction of second generation drugs with the archetype Clozapine. These are now the mainstay of treatment in several countries. Even after the introduction of 2nd generation antipsychotics, some drugs are likely to produce certain untoward effects like weight gain, hyperglycemia and dyslipidemia; drug-related cardiac changes (QTc prolongation) have also been reported. patients were divided randomly into two groups. One group was given Tab. Olanzapine 5-15mg/day & another group, Tab. Asenapine 5–10mg/day. The patients were given treatment for a period of 6 weeks and were followed once every week. Olanzapine showed better tolerability than Asenapine in patients with schizophrenia. The unique pharmacokinetic and novel pharmacodynamic properties of Olanzapine make it a safer antipsychotic when compared to FGAs. ramspsm@gmail.comResearch622016Efficacy,Tolerability,Asenapine,OlanzapineLakshmipathi BS,Subramanya BK Assistant Professor, Department of Pharmacology, KIMS, Koppal, Karnataka, India,Associate Professor, Department of Pharmacology, KIMS, Koppal, Karnataka, India.