164CLINICO – TOXICOLOGICAL PROFILE OF ORGANOPHOPHORUS POISONING AT A TERTIARY CARE HOSPITAL IN SOUTH INDIAOrganophosphorus (OP) compound poisoning is a major global health problem. According to World Health Organization, one million serious unintentional poisonings occur each year and an additional two million people are hospitalized for suicide attempts with pesticides. There are only few studies on epidemiological profile of OP poisoning case in this region, hence the present study was conducted. This was a retrospective study conducted in a tertiary care hospital in South India, data was obtained from medical records department from June 2012 to May 2014. Data was collected from causality and accident and emergency department records. Data regarding age, gender, occupation, type of OP poison, time to present to hospital, duration of hospitalization, and outcome were collected. Cases with snake bit, stings, insect bit, food poisoning, allergic reactions to drugs were not included in the study. Maximum cases were in males and in the age group of 31- 40 years. Most common use OP compound was Methyl parathion followed by Dimethoate. Most common time of consumption of poison and mortality was 12 noon to 6 pm and most common season was summer. The mortality rate was 10.1%, mortality was highest when the time lapse between consumption of poison and arrival at the hospital was 5-10 hours. OP poisoning is an agent of choice for suicidal poisoning especially in rural India because of its easy availability and lowcost. Acute complications are seen more frequently than chronic complication. No single factor is can be highlighted for mortality in OP poisoning. Therefore, rapid diagnosis, early and effective treatment will decrease the morbidity and mortality rate. These type of studies should be conducted at regular intervals which will help in identifying changing trends in poisoning and help to formulate effective diagnostic and management guidelines.mala.ravi124@gmail.comResearch712017Organophosphorus poisoning, Toxicological profile,Suicide,FarmersRavi D Mala,Sandeep B,N P Burte,T S HemalathaDepartment of Pharmacology, MNR Medical College, MNR Nagar, Sangareddy, 502294, India.,Department of Pharmacology, GITAM Institute of Medical Sciences & Research, Gitam University, Rushikonda, Visakhapatnam, 530 045, India,Department of Pharmacology, MNR Medical College, MNR Nagar, Sangareddy, 502294, India.,Department of Pharmacology, MNR Medical College, MNR Nagar, Sangareddy, 502294, India.