165A REVIEW ON ANTIEPILEPTIC DRUGS: NEWER DRUGS AND TARGETSEpilepsy is the common neurological disorder which drastically affects the quality of life and causes health and economic burden on society. The number of available antiepileptic drugs has increased substantially during the past 20 years. Drugs which were licenced since 1998 are Clonazepam, Lamotrigine, Tiagabine, Levetiracetam, Gabapentin, Lacosamide, Zonisamide and Rufinamide. There is need to discover more effective drugs for the treatment of resistant epilepsy as about a one third of patients remain resistant to available medical treatment. This review provides a brief description about the novel Antiepileptic Drugs (AED) which are having different mechanism of action. Retigabine has a unique ability to activate potassium channels. Ganaloxone is an allosteric modulator of GABA-A receptors acting through binding sites which are distinct from the benzodiazepine binding site. Belnacasan acts by inhibiting Caspase-1involved in IL-1beta production, which has a role in inflammatory processes & in the generation of epileptic discharges. The modified version of old drugs like eslicarbazepine acetate- congener of carbamazepine and Valnoctamide- congener of valproic acid are developed in order to make them more effective and tolerable. Recently FDA has approved AEDs like ezogabine (retigabine) and perampanel. Some drugs are in pipeline like brivaracetam, Carisbamate, Ganaloxone, Stiripentol, Belnacasan and Bumetanide. New applications of some existing drugs and new dosage formulations like intranasal diazepam & midazolam, diazepam autoinjection are in various phases of development.jain_charu2007@rediffmail.comReview712017Novel Antiepileptic Drugs,Eslicarbamazepine,Retigabine,PerampanelCharu Jain,Uma Advani, Lokendra Sharma,Monica Jain,Alka Bansal,Shivankan KakkarAssistant Professor, Department of Pharmacology, SMS Medical College, Jaipur, India.,Senior Demonstrator, Department of Pharmacology, SMS Medical College, Jaipur, India.,Professor, Department of Pharmacology, SMS Medical College, Jaipur, India.,Professor, Department of Pharmacology, SMS Medical College, Jaipur, India.,Assistant Professor, Department of Pharmacology, SMS Medical College, Jaipur, India.,Senior Demonstrator, Department of Pharmacology, SMS Medical College, Jaipur, India.