161HEMORHEOLOGICAL AND CEREBROPROTECTIVE ACTIVITY OF TECTONA GRANDIS L. EXTRACT IN RATS WITH CEREBRAL ISCHEMIAThe survey reveals that the plant is used in the treatment of urinary discharge, bronchitis, cold and headache, in scabies, used as a laxative and sedative, as duretic, anti-diabetic, analgesic and anti-inflammatory including blood disorders. To evaluate the hemorheological and cerebroprotective effect of ethanol extract of bark of Tectona grandis L. (EETG) against the global model of ischemia in rats. In the present study, the animals were pre-treated with EETG for a period of 1week (250 and 500 mg/kg) p.o. The animals were anaesthetized with thiopentone sodium (45mg/kg) and stroke was induced by Bilateral Carotid Artery Occlusion (BCAO) for defined period with aneurism clamps placed on both arteries and later (10 minutes) clamps were removed to allow reperfusion and animals were then returned to their cages. After 24 hours of reperfusion, the animal behaviors were evaluated by various methods such as behaviour pattern, Juvenile recognition, Motor activity, rotar rod test, Morris water maze test in stroke induced animals. The treatment was continued for another week after surgery with EETG. The present studies suggest that, there was a decrease in the escape latency in water maze in stroke induced (negative control) group. The group treated with 250mg/kg and 500 mg/kg EETG showed significant (P<0.01) improvement in the behaviour pattern, and spatial learning, which was confirmed in trial sessions in water maze test when compared with the negative control group. In conclusion, ethanol extract of bark of Tectona grandis L. produced cerebroprotective effects in global cerebral ischemia as evident from reduction in behavioral score, hyper locomotion and neuronal damage. vivekrm9@gmail.comResearch652016Tectona grandis L,Bilateral Carotid Artery Occlusion,Cerebral ischemiaV. Hari,A. Saravana KumarDepartment of Pharmacology, Sri Venkateswara College of Pharmacy, Chittoor, Andhra Pradesh – 517 127, Indi,Department of Pharmacology, Sri Venkateswara College of Pharmacy, Chittoor, Andhra Pradesh – 517 127, Indi