174IN VITRO ANTI-DIABETIC ACTIVITY OF LEAF EXTRACTS OF Ficus tinctoriaPancreas is the primary organ involved in sensing the organism’s dietary and energetic states via glucose concentration in the blood. In response to elevated blood glucose, it secretes insulin, which promotes glucose absorption into cells and subsequent utilization in energy production. Diabetes mellitus is a metabolic disorder which results from defects in insulin secretion where blood glucose level is elevated. Among the various methods of Diabetes management, herbal products are best alternative drugs with zero side-effects. The aim of our work is to evaluate the anti-diabetic activity of Ficus tinctoria leaf extracts in both polar and non polar solvents and the qualitative assessment of the bioactive photochemical using various physicochemical tests.The in vitro studies for alpha-amylase and alpha-glucosidase inhibitory action were performed using different concentrations of the extracts and the results were compared with that of a standard drug. Our findings revealed that among all the extracts, hydroalcholic and methanolic extracts showed efficient anti-diabetic activity. Methanolic extract of Ficus tinctoria leaves has shown an IC50 value 460 μg/ml for alpha-amylase inhibitory activity. The same extract was found to have an IC50 value 90.60 μg/ml for alpha-glucosidase inhibitory activity. Hydro alcoholic extract of Ficus tinctoria leaves has shown an IC50 value 90.60 μg/ml for alpha-glucosidase inhibitory activity and an IC50 value 362 μg/ml for alpha-amylase inhibitory activity.ushasri06@gmail.comResearch722017Ficus tinctoria,Diabetes mellitus,Anti-diabetic,hydroalcholic,methanolic,α-amylase,α-glucosidaseT. Swetha,N.V.L.Suvarchala Reddy,S.Ushasri,J.Ranjith kumar,G. Chiranjeevi,CH.PrsanthiGokaraju Rangaraju College of Pharmacy, Hyderabad, Telangana, India,Gokaraju Rangaraju College of Pharmacy, Hyderabad, Telangana, India, Sree College of pharmacy, Sujathanagar, Bhadradri- Kothagudem Dist, Telangana, India., Sree College of pharmacy, Sujathanagar, Bhadradri- Kothagudem Dist, Telangana, India., Sree College of pharmacy, Sujathanagar, Bhadradri- Kothagudem Dist, Telangana, India., Sree College of pharmacy, Sujathanagar, Bhadradri- Kothagudem Dist, Telangana, India.