176VITAMIN- D (Vit-D) STATUS AND CARDIOVASCULAR RISK IN PATIENTS WITH METABOLIC SYNDROME AMONG KERALA POPULATIONThe incidence of cardiovascular diseases (CVD) is on the increase globally. Although the role of traditional risk factors is already consolidated, the recent studies have suggested that the Vitamin-D (Vit-D) deficiency may contribute to the progression of cardiovascular diseases. Metabolic syndrome (MS) is a condition known to have an increased risk for CVD. It has been noted that the prevalence of MS and Vit-D deficiency is very high in Kerala population. Therefore the study was undertaken to analyze whether the status of Vit-D plays any role in the progression of cardiovascular risk in patients with MS in the given population. A cross-sectional study was conducted in a tertiary care teaching hospital. Test population comprised of people with any of the three risk factors as per Adult Treatment Panel III (ATP III) guidelines and control population was age and sex-matched healthy individuals. Demographic details, blood pressure, and blood samples were collected from each patient. Collected samples were used for analyzing the lipid profile, blood glucose level, Apo-A1, Apo-B, hs-CRP and LpPLA2. The values obtained were analyzed by using the appropriate statistical tool. The result showed that a higher value for lipid profile in the test population indicates a higher risk for CVD in the test population. The Apo -A1 level was significantly less and Apo-B level was significantly higher in test population compared to control group, which indicates an increased cardiovascular risk in the test population. The analysis showed a negative correlation between Vit-D and cardiac markers which indicate the role of Vit-D deficiency in the progression of CVD. The comparison of biomarkers in the different test groups showed a significant difference according to the Vit-D status of the individual. The findings are at par with various other studies conducted elsewhere and it establishes the relationship between Vit-D status and CVD. The outcome of the current study revealed that there is significant relationship between Vit-D level and risk for CVD in the Kerala population. The analysis clearly demonstrated the elevated levels of conventional and new biomarkers for cardiovascular risk prediction in test group. To establish the incidence of this relationship, a prospective, follow up study need to be conducted in futuremirshadpv@gmail.comResearch722017Metabolic syndrome,Vit-D status,Cardiovascular disease,Kerala PopulationMirshad P.V,Mohammed Rafiyuddin Rashed,Jithesh T.K,Jaideep Mahendra,Fasalu Rahiman OM,PremaGurumurthyResearch Scholar, Meenakshi Academy of Higher Education and Research, West K.Knagar, Chennai, Tamil Nadu, India,Associate professor, Department of Pharmacology, MES Medical College, Perinthalmanna, Kerala, India.,Associate professor, Department of Biochemistry, MES Medical College, Perinthalmanna, Kerala, India.,Professor, Department of Periodontics, Meenakshi Ammal Dental College, Chennai, Tamil Nadu, India., Tutor, Department of Pharmacology, MES Medical College, Perinthalmanna, Kerala, India.,Former Director (Research), Meenakshi Academy of Higher Education and Research, West K.K nagar, Chennai, Tamil Nadu, India.