177INFLUENCE OF BODYWEIGHT AND HEIGHT ON BLOOD CONCENTRATION OF ACENOCOUMAROL IN MECHANICAL HEART VALVE PATIENTSAnticoagulant effect of Acenocoumarol can be affected by various factors. Its effect is monitored through INR. We can also monitor the blood concentration of Acenocumarol. In this study we aimed to find out the effect of body weight and height on the trough and peak levels of 2 mg of Acenocoumarol. After ethics approvals and Patients who were satisfying the inclusion and exclusion criteria, were recruited after written informed consent either in English or Tamil. Age, sex, bodyweight and height of the participants were noted. 2 ml of blood samples were collected for measuring trough and Cmax levels. By using High performance liquid chromatography Concentration of Acenocoumarol was measured. One way analysis of variance (ANOVA) was used to compare trough and Cmax plasma concentration of Acenocoumarol of patients with different body weight and height groups, Pearson correlation was done to find out the correlation between body weight, height with trough and Cmax concentrations of Acenocoumarol. Totally 40 patients were recruited, In that 52.5 % were females and 47.5% were males. The mean INR was 2.7. The mean age was 46 years. Patients were divided into three categories based on body weight 40-50kg, 51-59kg, 60-85 kg. At 5 % level of significance there were no difference between different body weight groups and trough values. At 5 % level of significance there were no difference between different body weight groups and Cmax values. There was no correlation between body weight and trough values. There was no correlation between body weight and Cmax values. Patients were divided into three categories based on height 140-159cm, 160-165cm, 166-178cm. At 5 % level of significance there were no difference between different height groups and trough values. At 5 % level of significance there were no difference between different body height groups and Cmax values. There was no correlation between height and trough values. There was no correlation between height and Cmax values. Our study indicated that there is no significant difference in the trough and Cmax Concentration of Acenocoumarol between body weight and height. However, there are various factors other than body weight and height that can affect plasma concentration of Acenocoumarol, it has to be confirmed with larger samplesbhuvana1421@gmail.comResearch732017Body Weight,Height,Acenocoumarol Blood ConcentrationS. Bhuvaneshwari,Periyanarkunan Ramaiya Murugesan,M. Siva Selva Kumar,D. Jeyalakshmi Department of Pharmacology, PSG IMS & R, Peelamedu, Coimbatore, 641004, Tamilnadu, India.,Professor &HOD, Department of cardiothoracic surgery PSG IMS &R, Peelamedu, Coimbatore, 641004, Tamilnadu, India, Department of Pharmacology, PSG IMS & R, Peelamedu, Coimbatore, 641004, Tamilnadu, India.,Associate Professor, Department of Molecular Medicine and Therapeutics, PSG IMS &R, Peelamedu, Coimbatore, 641004, Tamilnadu, India.