179PATTERN OF ADVERSE DRUG REACTIONS DUE TO ANTINEOPLASTIC DRUGS AT REGIONAL ADR MONITORING CENTRE IN SOUTH INDIACancer is the second leading cause of death in the world. Antineoplastic agents are employed as part of a multimodal approach to treatment of many cancers and are extremely beneficial. Antineoplastic agents are highly toxic and are associated with severe adverse effects leading to economic burden and decreased quality of life. Pharmacovigilance studies are essential to identify and prevent adverse drug reactions (ADRs) as early as possible, to ensure the well-being of the patient at a reasonable cost. So the objective of the present study is to monitor and analyze the pattern of occurrence of ADRs to antineoplastic drugs reported to the ADR monitoring centre (AMC). This study was designed to monitor and analyze the pattern of occurrence of ADRs to antineoplastic drugs in the AMC at a tertiary care teaching hospital. The study was conducted for a period of 1 year, from Jan 2014 to Dec 2014. During the one year study period, out of 246 total ADRs reported in the ADR monitoring centre, 40 ADRs (16.3%) are due to antineoplastic drugs. 35 cases were reported from 26 (84%) females and rest 5 (16%) from males. Majority of the patients reporting ADRs were in the age group 40-59 years- 17 cases (54%). Most frequently observed ADRs included Alopecia-15 cases(37.5%), skin hypersensitivity reaction -9 cases(22.5%), vomiting- 7cases(17.5%). Maximum number of ADRs are reported with cyclophosphamide 11 cases(27.5%), Adriamycin 10(25%) and cisplatin 7(17.5%). ADRs can be better avoided or prevented only by active functioning of ADR monitoring and reporting center under pharmacovigilance programme of India. So awareness of pharmacovigilance among doctors and nurses can bring down the ADR incidence due to antineoplastic agents and there by decrease the health care budget in a developing country like India.umapharma08@yahoo.inResearch732017Adverse drug reactions (ADRs),Antineoplastic drugs,Pharmacovigilance,ADR monitoring centreJhansi vani CH,Uma Maheswari N,Meena Kumari A,Prasanthi T,Akhila Verma GDepartment of Pharmacology, Rajiv Gandhi Institute of Medical Sciences, Ongole, Andhra Pradesh, India.,Department of Pharmacology, Rajiv Gandhi Institute of Medical Sciences, Ongole, Andhra Pradesh, India.,Department of Pharmacology,Guntur Medical College, Guntur, Andhra Pradesh, India.,Department of Pharmacology,Guntur Medical College, Guntur, Andhra Pradesh, India.,Department of Pharmacology,Guntur Medical College, Guntur, Andhra Pradesh, India.