171INFLUENCE OF AZADIRACHTA INDICA IN HIGH DOSES OF PARACETAMOL ON SERUM ALANINE AMINOTRANSFERASE (ALT) AND ASPARTATE AMINOTRANSFERASE (AST) ACTIVITY IN RABBITSParacetamol is a recognized antipyretic, analgesic drug which produces hepatic necrosis in high doses. Azadirachta indica elaborates a vast array of biologically active compounds that are chemically diverse and structurally complex. Estimated levels of Serum aspartate aminotransferase (AST), Serum alanine aminotransferase (ALT) and Hepatoprotective action of Azadirachta indica in High doses of Paracetamol on serum alanine aminotransferase (ALT) and aspartate aminotransferase(AST) activity. ALT in all the groups including Control group (A) was (51.8±4.56 IU/L). Paracetamol treated group (B) the ALT level increased at 48 hours and continued to be high up to 60 days (136.4±20.73 IU/L) then decreased to (113.7±11.35 IU/L) at 90 day. AST in all the groups including Control group (A) was (22.5±1.23 IU/L). Appropriate antioxidant in appropriate doses as a matter of routine whenever hepatotoxic or potentially hepatotoxic drugs are prescribed. In Paracetamol treated group (B) the AST level increased at 48 hours and continued to be high up to 60 days (99.4±9.73IU/L) then decreased to (85.4±7.39 IU/L) at 90 day.Zaheermujawarjnmc@gmail.comResearch722017Azadirachta indica,,Paracetamol,Alanine aminotransferaseKale B.P,Mujawar Jahir RaufAssociate Professor, SMBT Medical College, Nandi Hills, Nandi Hills Igatpuri, Nashik, Maharashtra 422403, India,Assistant Professor, ACPM Medical College Morane, Sakri Road, Dhule, Maharashtra 424001, India.