173ASSESSMENT OF ADVERSE DRUG REACTIONS IN HIV PEDIATRIC PATIENTS IN A TERTIARY CARE HOSPITAL, KURNOOL, A.P, INDIABACKGROUND: Currently Anti-Retroviral Therapy (ART) regimens suppress viral replication, provide significant immune reconstitution, and have resulted in a substantial and dramatic decrease in AIDS related opportunistic infections and deaths in both adults and children. These medicines are often associated with adverse effects, with both short and long-term treatment. OBJECTIVES: This study was conducted to identify the type of adverse drug reactions in HIV pediatric patients and to minimize drug related toxicities in pediatric patients. METHOD: The prospective study was carried out in nodal ART centre of AP situated at Government hospital in Kurnool. The ADRs reported by physician were collected, analyzed and causality assessment was done. RESULTS: In the present study, (10.8%) gastritis, 13.2%) rashes, (8.4%) loss of appetite, (13.2%) giddiness, and (9.3%) facial discolouration were commonly reported ADRs. Out of 130 patients, 83(63.84%) patients of overall study population were treated with zidovudine based drug therapy, most of them having cough 22(26.5%), fever 19(22.89%) and pain in legs16 (19.27%) are observed in our study subjects 102 (63.7%) ADRs were possible by Naranjo causality assessment scale. CONCLUSION: Gastritis was the commonly reported ADR from ART. The findings of this study suggest that there is a need of intensive monitoring for ADRs in ARTs centres of Assam. ZLN based ART regimen is extremely safe, well tolerated, easy to see first line regimen in treating paediatric HIV patients (which is seen mostly better encouraging) the better clinical outcome, in our study, mean while new generation of ART regimen. Therefore, SLN produces severe toxicity of a rash, GI abnormalities, CNS toxicities (headache, insomnia) were observed in patients. In future, health care professionals (doctors, nurses, & pharmacists) are three pillars in maintaining health of the communities. Goals can be achieved by maintaining inter-disciplinary approach to provide a better health care for better outcome.sathishkumard11@gmail.comResearch722017ART,ADRs,GastritisD. Sathish Kumar,Eppili Bhavani,Ushasree Puneem,Motepalli Pandu Ranga Kumari,G.Yamini DurgaDepartment of Pharmacology, Kurnool Medical College, Kurnool, Andhra Pradesh, India.,Department of Pharmacology, Kurnool Medical College, Kurnool, Andhra Pradesh, India.,Department of Pharmacology, Kurnool Medical College, Kurnool, Andhra Pradesh, India.,Department of Pharmacology, Kurnool Medical College, Kurnool, Andhra Pradesh, India.,Department of Pharmacology, Kurnool Medical College, Kurnool, Andhra Pradesh, India.