182EFFECT OF AMLODIPINE AND CILNIDIPINE ON HEART RATE, BLOOD PRESSURE, ALBUMINURIA AND LIPID PROFILE IN STAGE I HYPERTENSIONBACKGROUND: Hypertension is a widespread public health problem and a major risk factor. Amlodipine, a calcium channel blocker is frequently used in the treatment of hypertension. Since Amlodipine primarily L-type calcium channel blocker (CCB) and thus reduces blood pressure, it stimulates sympathetic nerve activity leading to reflex increase in heart rate. Cilnidipine, a new type of CCB which can inhibit L- type calcium channels but also N-type calcium channels. We compare the clinical effectiveness of Amlodipine and Cilnidipine on blood pressure, heart rate, proteinuria and lipid profile in hypertensive patients. METHODS: The study was a prospective, open label comparison, a total of 76 patients were recruited for study in which 35 patients received 5-10mg Amlodipine and other 41 patients of same age groups received 10- 20mg Cilnidipine. 9 patients in Amlodipine group and 11 patients in Cilnidipine group were diabetic, 12 and 14 patients were proteinuric in Amlodipine and Cilnidipine and 11 and 9 were dyslipidemic in Amlodipine and Cilnidipine group respectively. RESULTS: There were no significant difference in demographic details and baseline characteristics except for TG. There were no significant differences in SBP, DBP, and heart rate in both groups. There was a significant improvement in Proteinuria with Amlodipine treatment and significant improvement in TG levels with Cilnidipine treatment. CONCLUSIONS: The study indicates that unlike Amlodipine, Cilnidipine which inhibits L-and N-type calcium channels will be useful for patients with hypertension and cardiovascular disease, dyslipidemia proves to be a better alternative to existing calcium channel blockers.drmanasa.cr@gmail.comResearch812018Hypertension, Cilnidipine, Amlodipine, Dyslipidemia, Albuminuria.Manasa C R,Balachandra G,Kalpana L,Veena R M,Bharath Kumar V DManasa C R,Balachandra G,Kalpana L,Veena R M4,Bharath Kumar V D