183A COMPARATIVE STUDY OF ANTINOCICEPTIVE EFFECT OF COMBINATION OF LAMOTRIGINE AND GABAPENTIN WITH TRAMADOL IN ALBINO RATSThe aim of the study was to compare the antinociceptive activity of combination of Lamotrigine and Gabapentin with that of Tramadol. After approval from Animal Ethics Committee, a total of eighteen (n=18) healthy male albino rats were divided into three groups of six each. Group A was control, Gr. B- Lamotrigine and Gabapentin treated and Gr.C – Tramadol treated. The test drug administered thirty minutes prior to the procedure once at weekly interval( on day 0,7,14,21 and 28)for upto 28 days. Haffner’s tail clip and formalin test were conducted to evaluate the antinociceptive effect. Antinociceptive effect of combination of Lamotrigine and Gabapentin was found to be comparable to that of the standard drug Tramadol in the second phase of formalin test. From the result obtained in this study we conclude that the coadministration of Lamotrigine and Gabapentin can be used as an alternative to Tramadol in chronic pain condition where Tramadol is contraindicated or intolerable. skvm80@gmail.comResearch812018Formalin test, Gabapentin, Haffner’s tail clip method, Lamotrigine ,Tramadol.Shashi kala kumari,Kusum Kumari,Satish Chandra,Manju GariShashi kala kumari,Kusum Kumari,Satish Chandra,Manju Gari