200THE RISE OF THE FIXED DRUG ERUPTIONFixed drug eruptions (FDE) are most commonly caused by non-steroidal anti-inflammatory drugs (NSAIDs) and antibiotics. The list of causative drugs changes with time and prescribing patterns but there has been no recent data on FDE seen in an outpatient setting in North India. Objective: We aimed to evaluate the epidemiology, clinical features and causative drugs in patients with FDE in North India. We analyzed and reviewedall patients seen with suspected adverse cutaneous reactions in the outpatient setting at DMCH Ludhiana, for one year. Using Causality Evaluation of the data was done for various parameters, which included demographics, drug and ADR characteristics and outcome of the ADRS Causality assessment was done by with three different scales. Naranjo Adverse Drug Reaction Probability Scale, the modified Hartwig’s severity scale and preventability criteria according to Schumock and Thornton scale. We identified 105 patients who were seen for suspected FDE. In Conclusion NSAIDS were the most frequent cause of FDE in our study. Other than that another routinely prescribed drug the combination pill that is a fluoroquinolone or cephalosporin with an antihelthminic drug, is high on the list of antimicrobials causing FDE and we caution that DMARDS, such as Leflunamide, should also be considered.poonamjatana@gmail.comResearch912019Fluoroquinolone, Cephalosporin, Antihelthminic.Poonam Jatana,Gurpoonam K Jatana,Sunil K Gupta,Sandeep KaushalPoonam Jatana,Gurpoonam K Jatana,Sunil K Gupta,Sandeep Kaushal