201EFFECTS OF GRADED DOSES OF FLAXSEED (Linum usitatissimum) ON LEARNING AND MEMORY AND THE POSSIBLE TOXIC EFFECTS IN SYSTEMIC ORGANS-AN EXPERIMENTAL STUDY IN ALBINO RATS30 Male Wistar albino rats were divided into 3 groups of 10 each Group1-Control group, Group2- Scopolamine group (positive control for learning &memory) Group 3- Scopolamine group pre treated with Flaxseed. Flaxseed was given orally in the graded doses of 20%, 40%,60%,80% in rat chow diet over a period of 40weeks. Scopolamine which induces transient amnesia was given in the dose of 1 mg /kg IP. Neuro behavioural tests were done using Pole climbing apparatus, Swim test apparatus, Elevated plus Maze and Water Maze at the end of 6weeks, 10weeks, 14weeks, 18weeks. 22weeks, 26weeks, 30weeks, 36weeks and 40weeks. Animals were sacrificed at the end of study and sent for histopathological examination and biochemical estimations. Euthanasia was done using Sodium pentothal overdose 100-200mg IP. Approval from IAEC was taken before starting the study. The data collected were analyzed using ANOVA, test of significance. Neurobehavioral tests showed significant improvement in learning and memory of the rats and histopathological examination revealed a significant protection of organs like Liver, Kidney and Brain by Flaxseed. Flaxseed can be taken as the food supplement of choice to improve learning and memory in Alzheimer’s disease royandregy@gmail.comResearch912019Scopolamine, linum usitatissimum, Neuro behavioural tests .Regina Roy,Ravi Indla,Fazulu Rahiman,Thangam Chinnathambi,Pallavi Kulkarni,Vidhyasagaran,Hana Abdul KareemRegina Roy,Ravi Indla,Fazulu Rahiman,Thangam Chinnathambi,Pallavi Kulkarni,Vidhyasagaran,Hana Abdul Kareem