203CIRCUMSTANCES OF ONSET OF HEPATONEPHRITIS RELATED TO THE USE OF ARTEMISININ-BASED COMBINATION THERAPIES (ACTS)The aim was to identify the main factors associated with unexpected serious cases of hepatonephritis related to antimalarials and especially to artemesinin-based combination therapies (ACTs). This descriptive study included 113 cases of hepatonephritis identified in the Ivorian pharmacovigilance database related to the use of antimalarials between 1 January 2007 and 30 July 2008. Out of the 273 medicines identified, antimalarials were the most involved (50.6%) especially artemisinin-based combination therapies (ACTs) (58%). Antibiotics accounted for 13.6%, particularly fluoroquinolones (1 in 3) and traditional herbal medicine for 12.1%. In more than 70% of cases, therapeutic associations were identified as a matter for misuse (43% of cases). On average, two drugs were associated including an antimalarial. The average duration of treatment was 5.2 days; three treatment-sequences were performed with short times between the different sequences. Nonrecommended prescribing practices have promoted the onset of serious and unexpected side effects of artemisinin-based combination therapies (ACTs). kamadg@yahoo.frResearch912019Risk factors,Pharmacovigilance,Hepatotoxicity,NephrotoxicityJean-Claude Yavo,Mamadou Kamagaté,Thérèse Daubrey-Potey,Affoussiata Bakayoko,Henri Dié Kakou Clinical Pharmacology Department of the Medical School of Abidjan. Felix Houphouet-Boigny University-Abidjan, Cote d’Ivoire and the Technical Committee, Clinical Pharmacology Department of the Medical School of Abidjan. Alassane Ouattara University-Bouake, Cote d’Ivoire and the Technical Committee, Clinical Pharmacology Department of the Medical School of Abidjan. Felix Houphouet-Boigny University-Abidjan, Cote d’Ivoire and the Technical Committee, Clinical Pharmacology Department of the Medical School of Abidjan. Felix Houphouet-Boigny University-Abidjan, Cote d’Ivoire and the Technical Committee,Clinical Pharmacology Department of the Medical School of Abidjan. Felix Houphouet-Boigny University-Abidjan, Cote d’Ivoire and the Technical Committee.