20CLOPIDOGREL - AN OVERVIEWClopidogrel has been approved and marketed globally with the primary indication being to reduce atherosclerotic events in patients with several co-morbid conditions due to stroke, myocardial infarction and cardiovascular disease Clopidogrel displays a selective binding on the platelet surface to adenylate cyclase-coupled ADP receptors, which is unique as compared with aspirin and other related drugs. The aim of this review to investigate pharmacokinetic and dynamic aspects of clopidogrel. A Medline search of published papers including pharmacokinetic,and pharmacodynamic information related to clopidogrel and mechanisms for clopidogrel resistance was done. Terms included in the primary search (up to March 2012) were: clopidogrel, proton pump inhibitors, and pharmacokinetics. All abstracts were reviewed and selected articles were retrieved. A secondary search was carried out from references of articles from the first search. Information from abstracts was also included. Relevant information on these aspects was registered and compiled. Our results suggest that, most of Cardiac patients with acute coronary syndrome (ACS) or other condition requiring antiplatelets therapy . Clopidogrel with Proton pump inhibitors (PPIs), Diltiazem , Ketconazole , Clarithromycin and some other (such as Cimetidine, Efavirenz and Ticlopidine) should be avoided. Almost all PPIs lost their efficacy when combine with Clopidogrel ,so if given individual it will be more effect for antiplatelets therapy with some exception .In this review we discussed more about Pharmacokinetics and Pharmacodynamics effect of Clopidogrel in Vascular patientskirankumar0814@gmail.comReview312013Clopidogrel,Pharmacokinetics,Pharmacodynamics,Drug interactionKiran Kumar P,Subash Vijayakumar,Narsimha Reddy YDepartment of Pharmacology, Vaagdevi College of Pharmacy, Ramnagar, Warangal, Andhra Pradesh, India,Department of Pharmacy Practice, Vaagdevi College of Pharmacy, MGM Hospital, Warangal, Andhra Pradesh, India.,Department of Pharmacology, Kakatiya university, Warangal, Andhrapradesh, India.