217COMPARISON OF INTRAVENOUS, INTRANASAL OR BUCCAL MIDAZOLAM AS RESCUE MEDICATION FOR TERMINATION OF SEIZURES IN ACUTE CONVULSIVE STATEThis study evaluated the anticonvulsant efficacy of midazolam to terminate seizures when administered by different routes (intravenous, intranasal or buccal route). This is a randomized controlled study done on 65 patients, who had seizure for more than 3 minutes or more than 3 seizures in 30 minutes. Patients were divided into 3 groups-Intra nasal midazolam (INM) group had 23 patients, 20 patients in intravenous midazolam (IVM) and 22 patients in buccal midazolam (BCM) group. Results showed that there was significant difference in decision to drug time [IVM (4.4+0.31), INM (1.2+1.1) and BCM (1.3+0.19) with p value of 0] , response time [IVM (1.6+2.1), INM(3.3+1.9), BCM(6.5+1.1) with p value 0]and Net time[IVM (5.7+1.8), INM(4.4+0.7),BCM (7.7+1.1) with p value 0]. But there was no significant difference in patients who did not respond to drugs, repetition of seizures and adverse effects. Present study shows that intranasal midazolam is one of the good options as rescue medication acute convulsion setting. This can be used in out of hospital setting alsoPelluri.v.sai@gmail.comResearch1012020 Acute seizures,Midazolam,Route of administration,intravenous,intranasal,buccalAnjani Priya.V,P.V.Sai Satyanarayana,V.Maruthi Ramakrishna raoAssistant Professor,Emergency Medicine Department, Kamineni Institute of Medical Sciences, Narketpally, Nalgonda, Telangana, India.,Head of the department, Emergency Medicine Department, Kamineni Institute of Medical Sciences, Narketpally, Nalgonda, Telangana, India,Assistant Professor,Emergency Medicine Department, Kamineni Institute of Medical Sciences, Narketpally, Nalgonda, Telangana, India.