21EVALUATION OF ANTIDIABETIC ACTIVITY OF POLYHERBRAL METHANOLIC EXTRACTIONPolyherbal therapy is said to be a current pharmacological principle having the advantage of producing maximum therapeutic efficacy with minimum side effects. The antidiabetic activity of a polyherbal formulation in alloxan induced diabetic rats was assessed using Alloxan β- cytotoxin induced chemical diabetes in a wide variety of wister albino rats. Methanolic extract of the poly herbal formulation, prepared from powder of plants Fruits of , Momordica charantia, stem and root of Tinospora cordifolia , hole plant of Andrographis peniculeta and wood of Pterocarpus marsupium and leaves of Gymnema sylvestre was subjected to phytochemical test and pharmacological screening of Antidiabetic activity at different dose level 300 mg/kg and 600 mg/kg. The formulation showed significant activity when compared to respective standard drug glipizide 5mg/kg.vvrajesham@gmail.comResearch312013Antidiabetic activity,Glipizide,Poly herbal formulationV. V. Rajesham,A. Ravindernath, D.V.R.N.Bikshpathi,S. Kiran KumarUniversity College of Technology, Department of Pharmacy, Osmania University, Hyderabad, Andhra Pradesh, India,University College of Technology, Department of Pharmacy, Osmania University, Hyderabad, Andhra Pradesh, India,Vijaya College of Pharmacy, Munganoor, Hyathnagar, Hyderabad, Andhra Pradesh, India.,Vijaya College of Pharmacy, Munganoor, Hyathnagar, Hyderabad, Andhra Pradesh, India.