22ANTILITHIATIC EFFECT OF ACHYRANTHES ASPERA LINN ON ETHYLENE GLYCOL-INDUCED LITHIASIS IN MALE ALBINO WISTAR RATSIn India, nayurivi Achyranthes aspera Linn (Amaranthaceae) is commonly used as a phytotherapeutic agent. The ethanolic extract of Achyranthes aspera Linn, was evaluated for its inhibitory potential on lithiasis (stone formation), induced by oral administration of 0.75% ethylene glycolated water to adult male albino Wistar rats for 28 days. The ionic chemistry of urine was altered by ethylene glycol. This elevated the urinary concentration of crucial ions viz. Calcium, oxalates and phosphate, there by contributing to renal stone formation. The ethanolic extract, however, significantly (p<0.01) reduced the elevated level of these ions in urine. Also, it elevated the urinary concentration of magnesium which is considered as one of the inhibitors of crystallization. The histopathological findings also showed signs of improvement after treatment with the extract. All these observations provided the basis for conclusion that this plant extract inhibits stone formation induced by ethylene glycol treatment.pharmbeula@yahoo.comResearch312013Anti lithiatic,Achyranthes aspera Linn,Ethylene Glycol,Urolithiasis,Hyperoxaluria,AmaranthaceaeS.Janet Beula,Raju Bathula,K.Ramadevi,G.E Suhasini,M.Nirmala,N.Sriram,Department of Pharmaceutical Chemistry, Avanthi Institute of Pharmaceutical Sciences, JNTU, Hyderabad, Andrapradesh, India.,,Department of Pharmaceutical Chemistry, Avanthi Institute of Pharmaceutical Sciences, JNTU, Hyderabad, Andrapradesh, India.,Department of Chemistry, Osmania University, Hyderabad, Andhra Pradesh, India.,Department of Chemistry, Osmania University, Hyderabad, Andhra Pradesh, India.,Department of Pharmaceutical Chemistry, Avanthi Institute of Pharmaceutical Sciences, JNTU, Hyderabad, Andrapradesh, India.,Smt.Sarojini Rammulamma College of Pharmacy, Mahabub Nagar, Andhra Pradesh, India.