236ABNORMAL HEMATOLOGICAL PARAMETERS INVESTIGATED IN DENGUEDengue fever is caused by one of four serotypes of the dengue virus (DEN-1, DEN-2, DEN-3, and DEN-4) that belongs to the genus Flavivirus and the family Flaviviridae. Dengue fever is spread to humans through the bite of a female Aedes aegypti mosquito infected with one of four virus serotypes. The key vector in India is this mosquito, which is a domestic species that has adapted to urban conditions. Dengue fever is an acute febrile condition marked by a 3-5-day fever, severe headache, myalgia, retro-orbital pain, anorexia, gastrointestinal disturbances, and a rash. From August to December 2017, 208 cases of clinically suspected dengue infection were admitted to our hospital's Medicine Department for infectious diseases. The month of December 2017. 100 cases were selected from the total of 208. patients who have tested positive for dengue fever In order to assess the severity of infection, researchers looked into it in depth. We looked at all of the patients' peripheral smears, and found that 49 percent of them had reactive lymphocytosis with atypical lymphocytes. Plasmacytoid lymphocytes with nucleus pushed to periphery, slicing of nucleus, irregular nucleus boundary, and bilobed nucleus were among them. Few scholars have looked into the smears and come up with identical results. The findings are useful in characterising the disease's progression as well as the haematological dynamics involved, and they can be used as screening methods by physicians to monitor early therapeutic responsenavyaavr24@gmail.comResearch1112021Dengue Fever,Diagnosis,Pathology,Hematological Profile,AntigenDr. Navyaa V.R,Dr. Sivaranjan DAssociate Professor,Nimra Institute of Medical Sciences, Nimra nagar Ibrahimpatnam Jupudi Vijayawada, Andhra Pradesh- 521456, India.,Professor, Nimra Institute of Medical Sciences, Nimra nagar Ibrahimpatnam Jupudi Vijayawada, Andhra Pradesh- 521456, India.