238A ROLE OF BIOCHEMICAL PARAMETERS OF CHRONIC LIVER DISEASESinusoidal portal hypertension is categorized by rise in confrontation to blood flow of hepatic sinusoids. This has two components; one is fibrotic disruption of liver architecture and another due to contractility variations of the stellate cells of the liver. In addition, changes in the hepatic sinusoidal myofibroblasts. Sensitivity of the hepatic sinusoidal cells to vasoactive mediators like nitric oxide (NO), prostaglandins and endothelins develops. The production of sinusoidal NO is impaired due to increased expression of caveolin (caveolin are intracellular lipid particle, they transports lipids among organelles, regulate vesicular trafficking of endothelium and signal transduction) in cirrhotic patients. In contrast to it, there is elevated level of NO in the splanchnic arterial circulation that causes vasodilation, along with other mediators like endogenous cannabinoids and carbon monoxide (CO) especially seen in patients with cirrhosis16,17. In persons with cirrhosis, the hyperdynamic state is normal due to the compensatory mechanisms of initial vasodilatation in the splanchnic arterial circulationVijayKumar@gmail.comResearch1022020Biochemical,Chronic Liver Disease,Carbon Monoxide,Creatinine Kinase Mb,Cirrhotic Cardiomyopathy,Cyclic Adenosine MonophosphateDr.Vijay Kumar,Dr.Harika UppalapatiAssistant Professor Balaji Medical College, Chromepet, Chennai, Tamilnadu, India.,Assistant Professor Balaji Medical College, Chromepet, Chennai, Tamilnadu, India.