231TOTAL INTRAVENOUS ANAESTHESIA: PROPOFOL-KETAMINEVS PROPOFOL-FENTANYLGeneral anaesthesia should provide quick and pleasant induction, predictable loss of consciousness, stable operating conditions, minimal adverse effects, rapid and smooth recovery of protective reflexes and psychomotor functions. Various drugs have been tried from time to time in TIVA. Since no single drug can provide all the characteristics of an ideal intravenous agent, several drugs are used in different combinations to provide balanced anaesthesia in TIVA, that is, amnesia, hypnosis and analgesia. This study was conducted to evaluate and compare two drug combinations of TIVA using propofol–ketamine and propofol–fentanyl and to study the induction, maintenance and recovery characteristics. A prospective randomized study was conducted on 60 subjects between 20 to 50years, posted for minor day-care gynaecological surgeries. METHODS: The subjects were randomly allocated into 2 groups Propofol-Ketamine (PK) group and Propofol-Fentanyl (PF) group. Those in PK group were induced with Propofol 1mg/Kg and Ketamine 1 mg/Kg and anaesthesia was maintained with Propofol infusion 2 mg/Kg/hr and Ketamine infusion 2 mg/Kg/hr. Results: Demographic data were comparable in both the groups. The mean pulse rate, systolic, diastolic blood pressures immediately after induction were significantly more in group PK when compared to group PF (p<0.05)Of the 60 patients in group PK, 4 patients had postoperative excitation, 5 patients had secretions and 2 patients Complained of nausea in the post-operative period. Of the 60 patients in group PF, 2patients complained of nausea in The post-operative period.Comparison of Mean Sedation Score the results of this study suggest that both propofol-ketamine and propofol-fentanyl combinations produce rapid and safe anaesthesia with minor hemodynamic fluctuations. In conclusionwe recommended that both propofol-ketamine and propofol-fentanyl can be used as combinations in TIVA for day care surgeries where minimal side effects and early recovery are desired..docbalaganesh@gmail.comResearch322013Anaesthesia,Ketamine,Propofol,Fentanyl,General AnaesthesiaBalaganesh S,Jaikumar SDepartment of Anaesthesiology, Sri Lakshmi Narayana Institute of Medical Sciences, Pondicherry. India.,Department of Pharmacology, Sri Lakshmi Narayana Institute of Medical Sciences, Pondicherry. India.