242EVALUATION OF ANTI-CONVULSANT AND ANTI-ANXIETY ACTIVITY OF ETHANOLIC EXTRACT OF ANTIGONON LEPTOPUSThe objective of the present study was to evaluate the anticonvulsant and antianxiety Activity of the ethanolic extract of Antigonon leptopus ( EEAL). After preliminary Phytochemical evaluation, acute oral toxicity, antianxiety activity of ethanolic extract of Antigonon leptopus at doses of 125 and 250 and 500 mg/ kg was assessed using elevated-plus-maze (EPM), open field test (OFT) models and anticonvulsant effect was assessed using maximal electroshock (MES) and Isoniazid (INH) induced convulsion models. Oral administration of EEAL for seven days significantly increased number of entries and time spent in open arms in EPM model, number squares crossed and number of rearings in OFT. Further , EEAL ( 125 and 250 and 500 mg / kg ) showed protected the mice against the isoniazid induced convulsions ; it causes significant( p < 0.01 and p < 0.001 ) dose dependent increase the latency of convulsion. Treatment With EEAL reduced the duration of the tonic hind limb extension induced by Electroshock. Mechanistic studies showed significant improvement in brain GABA Levels after after Antigonon leptopus treatment.Thamotharan@gmail.comResearch1122021Antigonon leptopus,Antianxiety,AnticonvulsantThamotharan G,Gayathri K,V.Suresh,N. Senthilkumar,G.Muthukumaran,R.Kannan,N.DeepanDepartment of Pharmacology, JKKMMRF’S College of Pharmacy, Komarapalayam, Tamilnadu, India.,Department of Pharmacology, JKKMMRF’S College of Pharmacy, Komarapalayam, Tamilnadu, India.,Department of Pharmacology, JKKMMRF’S College of Pharmacy, Komarapalayam, Tamilnadu, India.,Department of Pharmacology, JKKMMRF’S College of Pharmacy, Komarapalayam, Tamilnadu, India.,Department of Pharmacology, JKKMMRF’S College of Pharmacy, Komarapalayam, Tamilnadu, India.,Department of Pharmacology, JKKMMRF’S College of Pharmacy, Komarapalayam, Tamilnadu, India.,Department of Pharmacology, JKKMMRF’S College of Pharmacy, Komarapalayam, Tamilnadu, India.