254AN IMPACT OF HYPOMAGNESEMIA MANAGEMENT FOR TYPE 2 DIABETES MELLITUS PATIENTSDistal convoluted tubule contributes to reabsorption of 5 to 10% of the filtered magnesium through active transcellular pathway. Magnesium absorption from the DCT has been found to occur through TRMP6. Mutations involving the TRMP6 leads to hypomagnesemia and secondary hypocalcemia, Reabsorption from this segment is important because it determines the concentration of magnesium in urine. Patients should be subjected to examination of power of the muscles, sensory system examination and vibration sense. Sensory system is examined on all the four limbs individually. Vibration is examined using 128Hz tuning fork. Touch is examined using mono filament. Autonomic functions in diabetes mellitus patients are monitored by recording the changes noted in blood pressure and heart rate in response to special maneuvers like thermoregulatory sweat test, head up tilt test and valsalva manuvers. Diabetes mellitus refers to metabolic disorders associated with chronic hyperglycemia with changes in carbohydrate, protein and fat metabolism which results from defects occurring in insulin secretion or insulin action or both. It is the commonest metabolic disorder in the world and the leading cause of death and disability. Complications of Diabetes mellitus include chronic damage, dysfunction and failure of various organs mainly affecting the eyes, kidneys, heart and blood vessels. Various minerals and vitamins acts as cofactors in regulation of insulin secretion and action ,among which magnesium plays a key role.Sivaprasad@gmail.comResearch652016Hypomagnesemia,Hypocalcemia,Reabsorption,MagnesiumDr. K. Siva PrasadDepartment of General Medicine, Sree Balaji Medical College and Hospital, Chennai-600044, Tamilnadu, India