259COMPARISON OF THE EFFICACY AND SAFETY OF CO-AMOXICLAV AND CEFUROXIME AXETIL IN THE TREATMENT OF ACUTE SINUSITIS IN A TERTIARY CARE HOSPITALAcute sinusitis is a frequent upper respiratory illness that can become quite serious if treated incorrectly. The focus of this research was to compare & evaluate the effectiveness of cefuroxime & co-amoxiclav in treating acute sinusitis in a tertiary care hospital. In 2009, researchers conducted a randomized clinical study to compare the efficacy of 2 oral antibiotics, cefuroxime and co-amoxiclav, in treating acute sinusitis.The research included a total of 120 participants. The conjunction of suborbital discomfort, purulent rhinorrhea, & purulent discharge on the middle nasal meatus led to the clinical diagnosis of acute sinusitis. All of the patients were also radiographically checked to corroborate their findings. Patients were randomly randomised to receive either cefuroxime axetil 250 mg BD daily for 10 days (n=72) or Co-amoxiclav 500/125 mg BD daily for 10 days (n=48). Patients' reactions to therapy were evaluated both during & after therapy. Patients treated with cefuroxime or co-amoxiclav had a favorable clinical result (cure or improvement of symptoms) in 86.11 percent (62/72) and 72.91 percent (35/48) of the clinically evaluable patients, respectively (p >0.05). Cefuroxime (BD daily) appears to be equally beneficial as co-amoxiclav (BD daily) in the treatment of acute sinusitis, according to the findings of this studyrushika_modi@yahoo.comResearch1212022Acute sinusitis,Cefuroxime axetil,Co-amoxiclav,Rhinorrhoea,Streptococcus pneumoniaeDr. Rushika Shaileshkumar Modi1,Dr. Swapnil Modi,Dr. Mark Andrew SubhashchandraAssistant Professor, Department of Pharmacology, Nootan Medical College and Research Centre, S K University, Visnagar - 384315, North Gujarat, India,Senior Resident, Critical Care Department of Anesthesia, Mahatma Gandhi Medical College and Hospital, Mhatma Gandhi University of Medical Sciences and Technology Jaipur – 302022, Rajasthan, India.,Associate Professor, Department of Pharmacology, Chirayu Medical College and Hospital, Bhopal, Madhya Pradesh – 462030, India.