252TOPICAL SEVOFLURANE'S SAFETY AND EFFICACY IN THE MANAGEMENT OF CHRONIC SKIN ULCERSVascular ulcers are a form of skin ulcer that is characterized by a painful sore (usually on the lower legs) and tissue disintegration that mostly affects the epidermis, but may also affect the dermis and subcutaneous fat. Venous ulcers account for 70% of all vascular ulcers and are distinguished by a moist granulating base that oozes venous blood when manipulated and an irregular margin. Stasis dermatitis can be present in the tissue surrounding these ulcers. Ulcers can be arterial, neurotrophic, or diabetic in the remaining 30% of cases. Vascular ulcers affect an estimated 1.0–3.6 percent of adults in developing countries at some stage in their lives, putting a major strain on healthcare systems. Vascular ulcers are linked to diseases like hypertension, obesity, diabetes, and atherosclerosis, despite the fact that their cause is usually multifactorial. The aim was to study the effectiveness and tolerability of using direct topical sevoflurane to treat vascular ulcers in a group of patients who were not responding to conventional pharmacologic treatments. At the start of the study, sixteen patients who met the inclusion criteria were randomly assigned to one of two study groups. Table 1 summarizes the baseline demographic and epidemiologic characteristics. The ulcer surface's average mean S.D. Overall, the mean S.D. number of ulcers per patient was 2.35+- 1.20, with a mean S.D. period of 26.2, 23.2 months from diagnosis to first sevoflurane instillation. The mean S.D. pain score at baseline (as calculated by VAS) was 7.5 1.5 points.Nambala@gmail.comResearch732017Efficacy and Safety of Drug,Adverse Events,Anesthetics,SevofluraneDr. Nambala Venkata Uday GanapathiDepartment of Anesthesia, Sree Balaji Medical College and Hospital, Chennai-600044, Tamilnadu, India