265OFLOXACIN DELIVERY BY AN ION-ACTIVATED IN-SITU GELLERThe rapid pre-corneal clearance of the medication caused by standard ophthalmic solutions' poor bioavailability and therapeutic response can be solved through using in situ gel systems mainly, that are injected into the eyes as droplets and subsequently experience a sol-gel transformation in the cul-de-sac. In this study, the ion-activated in situ gelation concept was used to design and evaluate an ophthalmic delivery system ofloxacin. In order to increase viscosity, sodium alginate was combined with Hydroxy Propyl Cellulose, a gelling substance. The alginate/HPC solution maintained the medication better in vitro than either alginate or HPC individually. There was therapeutic efficacy, sterility, stability, and sustained release of drug from the formulations. This technology has been demonstrated to be a client-friendly, cost-effective replacement for traditional eye dropsdrgmathipharm2017@gmail.comResearch1212022Ophthalmic delivery systems,therapeutic effect,sodium alginate,naso-lacrimal duct, eye drops,in situ gellingR.Gandhimathi,M.Archana,A.Saravanakumar,R. Meenakshi SudaramDepartmentof Pharmaceutical Chemistry and Analysis, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Pallavaram, Chennai-600117, Tamilnadu, India,GRT Institute of Pharmaceutical Education and Research, Thiruttani- 631209, Tamilnadu, India,GRT Institute of Pharmaceutical Education and Research, Thiruttani- 631209, Tamilnadu, India,GRT Institute of Pharmaceutical Education and Research, Thiruttani- 631209, Tamilnadu, India