266HEPATOPROTECTIVE ACTIVITY OF TRAGOPOGON GRAMINIFOLIUS DC AQUEOUS EXTRACT IN CCL4-INDUCED HEPATOTOXICITY IN MICEIndian traditional medicine uses Tragopogon graminifolius DC to protect the stomach and heal wounds. Mice treated with carbon tetrachloride (CCl4) were given tragopogon graminifolius DC aqueous extract to investigate its hepatoprotective properties. A total of five groups of 55 male mice (n=11) were formed. Three groups were present: Group B (untreated) got CCl4 (55 percent in olive oil, 0.001l/kg; i.p.); Groups C, D, and E received CCl4 and TGAE (35, 95, and 260 mg/kg, respectively). Group A (controlled) obtained olive oil (0.001l/kg) and distilled water (0.001l/kg). The mice in each sample were put to death 50 days after the beginning of the treatment, and biochemical and histological data were evaluated. The statistical analyses were performed using a one-way analysis of variance and the Duncan's test. When various doses of TGAE (particularly TGAE260) were taken, ALP, AST, ALT, Cholesterol, LDL, and HDL levels increased considerably (p ? 0.06) in the TGAE group compared to non - treated group. Several dosages of TGAE (particularly TGAE260) significantly reduced liver mass and size when compared to the untreated group (p ?0.06). The results of the present study showed that under the present experimental conditions, TGAE indicated hepatoprotective abilities against CCl4 induced liver damage in micedrvrvkk@gmail.comResearch922019Hepatoprotective activity,Tragopogon graminifolius extract,male mice,acute liver injuriesChavala Gayatri DeviAssistant Professor of Pharmacology, Sree Balaji Medical College and Hospital, Shankar Nagar, Chromepet, Chennai, Tamil Nadu 600044, India.