268ANTICONVULSANT AND ANALGESIC EFFECTS OF EMBLICA OFFICINALIS ON EXPERIMENTAL MODELS IN MICEEmblica officinalis, commonly known as amla in the subcontinent, is an important medicinal plant used for several health benefits. E. officinalis fruits have also been reported to have variety of effects due to the presence of tannoids, tannins, vitamin C and flavonoids. The present study was thus designed to investigate the anti-convulsant and analgesic effect of E. officinalis fruit’s extract in acute experimental studies. In convulsion models, increasing current electroshock test (ICES), maximum electroshock seizure (MESS) and pentelenetetrazole (PTZ) model were used. For testing analgesic effects tail flick test and formalin induced pain response were recorded. It was found single dose administration of E. officinalis (200, 400 & 600 mg/kg) p.o. significantly (p<0.001) decreased the duration of tonic hind limb extension in MESS, increased the latency to onset and decrease duration of myoclonic jerks as compared to the control group in PTZ convulsions. In ICES it was observed to increase seizure threshold current in the doses of 400mg/kg and 600mg/kg significantly as compared to the control group (p<0.001).E. officinalis in all three doses significantly (p<0.001) increased the tail flick latency as compared to control group. In formalin induced pain in early phase decreased the duration of licking response to as compared to the control group significantly (p<0.001) in the doses of 400mg/kg and 600mg/kg. In the late phase the duration was reduced with all three treated doses of E. officinalis when compared with control group. These results suggest that E. officinalis possesses anti-convulsant and analgesic properties in acute administration. It may be useful for the treatment of epilepsy and pain management. It’s mechanism in the management of pain and epilepsy needs further explorationtanwarkrishna@yahoo.co.inResearch1222022officinalis,anticonvulsant,analgesicUmesh Suranagi, Novy Gupte,Krishna Tanwar,Vijay ChamleAssociate professor, Department of pharmacology, Lady Hardinge Medical College, New Delhi, India,Assistant professor, Department of pharmacology Army College of Medical Sciences, New Delhi, India,Associate professor, Department of pharmacology, Lady Hardinge Medical College, New Delhi, India,Manager, Asia Pacific Medical Affairs Johnson and Johnson Consumer Health. Mumbai, India