269PHARMACOLOGICAL EVALUATION OF AQUEOUS EXTRACT OF LEAVES OF MERREMIA EMARGINATAUlcers are sores or open wounds that occur on the skin or along the lining of the digestive tract due to loss of tissue. They are also defined histologically as a breach in the mucosa of the alimentary tract that extends through the muscularis mucosa in to the submucosa layer. The aim of our study is to evaluate the aqueous extract of leaves of Merremia emarginata(In vivo and In vitro)".The leaves under investigation (Merremia emarginata) was successfully extracted using water as the solvent. The Phytochemical studies revealed the presence of alkaloids, Saponins, Tannins, Phloba tannins, Flavonoids, Glycosides, reducing sugars and terpenoids. Antiulcer activity was performed in vivo using indomethacin induced gastric ulceration rat model and the extract was found to possess good ulcer protective properties. The extract at concentration of 500mg/kg, produced significant reduction in the ulcer index as that of standardeeswar24@gmail.comResearch1222022Merremia emarginata,Ulcers,In vivo and In vitro,Anti-ulcerP. Arthanariswaran,Akmal Ali BAigProfessor, Department of Pharmacognosy, Arulmigu Kalasalingam College of Pharmacy, Krishnankoil, Tamilnadu – 626 126, India,Professor, Department of Pharmacy Practice, Sri Krishna Chaithanya college of Pharmacy, Madanapalle, Andhra Pradesh – 517 325, India