277A STUDY TO EVALUATE THE IMPACT OF NEW ANTICOAGULANTS IN HOSPITALSNewer, though more expensive, oral alternative anticoagulants have been developed as a result of the shortcomings of current anticoagulants. The aim of this research is to determine how the new anticoagulants dabigatran and rivaroxaban will affect utilization and costing in local hospitals. According to the results of a prospective two-week clinical audit, a preliminary costing analysis was conducted. Medical records of Ryde Hospital patients were analysed to determine current anticoagulation management. From key clinical trials, the occurrence of stroke/VTE and event of bleeding was gathered in order to demonstrate possible cost implications of using these new agents. A total of 67 patients were studied for their prophylaxis of VTE/stroke with warfarin or enoxaparin (n=46). Most patients (65.2% of those with active AF, 34.8% of those with active VTE) were eligible for newer oral anticoagulants (warfarin: 65.2% of those with active AF, 34.8% of those with active VTE; enoxaparin: 100% of those with active VTE). In comparison with warfarin and enoxaparin, dabigatran was seen to be more cost-efficient for VTE/stroke prevention because its therapeutic monitoring costs were substantially lower. When supplier rebates (33% of the costs) are factored into the costing, Rivaroxaban is cheaper than warfarin and enoxaparin. Dabigatran and rivaroxaban are considered cheaper than enoxaparin and warfarin in this study, as were newer anticoagulants, dabigatran and rivaroxaban. As anticoagulated patients are managed in hospitals, these agents may offer both clinical and economic benefitsKrupalinivadapalli2000@gmail.comResearch1312023Anticoagulants,Costs and Cost Analysis,AustraliaKrupalini Vadapally,Meruga Prashanthi, Jarpala Rambabu,Ujwala S, Neelam SreejaKLR Pharmacy College, Paloncha, Bhadradri Kothgudadm, Telangana- 507115, India,KLR Pharmacy College, Paloncha, Bhadradri Kothgudadm, Telangana- 507115, India,KLR Pharmacy College, Paloncha, Bhadradri Kothgudadm, Telangana- 507115, India