271IN VIVO STUDY OF ANTINOCICEPTIVE ACTIVTY ON PLANT EXTRACT OF KALANCHOE PINNATA LEAVES (Lam.)PERSKalanchoe pinnata (family: Crassulaceae) is an important plant which has many traditional medicinal uses. It was found that this plant showed various pharmacological activity such as Anthelmintic, Wound healing, Hepatoprotective, Antinociceptive, Antimicrobial, Anti-analgesic, Anti-inflammatory. Kalanchoe pinnata was used to Wounds, Peptic ulcer, Skin Disease and Rheumatism. It has high wound healing properties. It used to treat stones in gall bladder. The in vivo thermal (hot plate test) models of nociception were used to evaluate the extract Anti-nociceptive activityvsureshsph@mail.comResearch1312023Kalanchoe pinnata leaves,Nociceptive,Anti-nociceptive,Hot plate test,MiceDr. Suresh V,Dr. Senthil Kumar K L,Muthuraj K,Nandhini S,Naveen Kumar GProfessor, Department of pharmacology, Sri Vijay Vidyalaya College of Pharmacy, Dharmapuri, Tamilnadu, India,Principal, Sri Vijay Vidyalaya College of Pharmacy, Dharmapuri, Tamilnadu, India,Sri Vijay Vidyalaya College of Pharmacy, Dharmapuri, Tamilnadu, India,Sri Vijay Vidyalaya College of Pharmacy, Dharmapuri, Tamilnadu, India,Sri Vijay Vidyalaya College of Pharmacy, Dharmapuri, Tamilnadu, India