272EFFECT OF BISACODYL ON RATS WITH SLOW TRANSIT CONSTIPATIONThe effects of bisacodyl on slow transit constipation (STC) in rats were studied. STC, STC, and STC were three groups with 45 female Wister rats. bisacodyl. Interstitial neurons of Cajal (ICC) with c-Kit protein expression were determined using immune histo chemistry On the 100th day after diphenoxylate treatment, the STC group had lower body mass and defecation volume than the control group, but greater dry feces weight and longer intestinal transit time. The three groups differed in defecation frequency, feces dry weight, and intestinal transit time. It had more feces, less dry weight, and a faster intestinal transit time that STC. In addition, the STC group's colon wall had ICC basement membrane disintegration. The nucleus shrank to various degrees, and the link between ICC with surrounding cells were disrupted. Furthermore, the STC group had considerably lower c-Kit expression than just the control group. The STC bisacodyl sample had a considerably better link between ICC and adjacent cells than just the STC sample, and also the number and ICC with c-Kit expression were both enhanced. Bisacodyl reduces STC severity in rats by boosting ICC and c-Kit expressionPrabhu@gmail.comResearch922019Constipation; Bisacodyl; c-KiVijay Prabu EAssistant Professor, Department of Pharmacology, Aarupadai Veedu Medical College and Hospital, Kirumampakkam, Puducherry – 607402