27ANTIDIARRHOEAL ACTIVITYOF COUROUPITA GUIANENSIS LEAVES ON CASTOR OIL INDUCED DIARRHOEA IN ALBINO RATSThe species of Couroupita are widely distributed in India and used as traditional medication for a variety of indications. The present investigation was aimed to study the anti-diarrhoeal activity of methanolic and aqueous extracts of Couroupita guianensis leaves on castor oil induced diarrhoea in albino rats. Fresh plants were collected, subjected to airdrying in a shade, the leaves were isolated and powdered. The extracts were prepared by hot soxhlet extraction. The albino rats were divided into 4 groups of control, standard, aqueous extract and methanolic extract treated groups for the study with standard dose containing a 1mg/kg of loperamide and test doses of methanolic and aqueous extracts in control solution (1% w/v sodium lauryl sulphate). The castor oil fed animals were ingested with standard and test doses and the faeces were collected and weighed separately every hr, up to 4 hr. In castor oil induced diarrhoea both the methanolic and aqueous extracts along with standard loperamide showed significant reduction in diarrhoeal episodes. The student t-test values of 100mg/kg methanolic extract and 100mg/kg aqueous extract were 0.040 and 0.044 respectively and compared to that of standard which has 0.042 (p<0.05) indicating that there was no significant difference exists between these values and that these doses were equally effective when compared with that of standard drug. A dose of 100mg/kg of methanolic extractor 100mg/kg of aqueous extract of Couroupita guianensis dried leaves could be employed for anti-diarrhoeal activity. It was concluded that dried leaf extracts of Couroupita guianensis could be employed as anti-diarrhoeal agents.malairx@gmail.comResearch322013Castor oil induced diarrhoea,Couroupita guianensisA. Elumalai,M. Chinna Eswaraiah,Koppula Naresh,Ranjith Kumar,Anusha Meruva,Cherukuri VidhyulathaDepartment of Pharmacognosy, Anurag Pharmacy College, Ananthagiri (V), Kodad (M), Nalgonda Dt, A.P, India-508 206.,Department of Pharmacognosy, Anurag Pharmacy College, Ananthagiri (V), Kodad (M), Nalgonda Dt, A.P, India-508 206.,Department of Pharmacognosy, Anurag Pharmacy College, Ananthagiri (V), Kodad (M), Nalgonda Dt, A.P, India-508 206.,Department of Pharmacognosy, Anurag Pharmacy College, Ananthagiri (V), Kodad (M), Nalgonda Dt, A.P, India-508 206.,Department of Pharmacognosy, Anurag Pharmacy College, Ananthagiri (V), Kodad (M), Nalgonda Dt, A.P, India-508 206.,Department of Pharmacognosy, Anurag Pharmacy College, Ananthagiri (V), Kodad (M), Nalgonda Dt, A.P, India-508 206.