308IMPACT OF ISCHEMIA/REPERFUSION ON HEPATOCYTE APOPTOSIS IN STEATOTIC LIVER: INSIGHTS FROM A MOUSE MODEL AND THERAPEUTIC POTENTIAL OF AMINOGUANIDINEThe study investigated apoptosis of hepatocytes following ischemia and reperfusion in steatotic liver. Using a mouse model, liver histology, serum alanine aminotransferase, and peroxynitrite levels were assessed after partial hepatic ischemia. Steatotic livers exhibited increased peroxynitrite levels post-reperfusion, with upregulated caspase 9 and 3, indicating significant hepatocyte apoptosis. Aminoguanidine treatment reduced alanine aminotransferase levels and improved survival in mice with steatotic livers post-reperfusion, highlighting susceptibility to ischemia/reperfusion injury in steatotic livers.Anurag@gmail.comResearch922019Steatotic liver, Ischemia/reperfusion injury, Hepatocyte apoptosis, Alanine aminotransferase, Aminoguanidine treatment.Dr Anurag Chitranshi,Dr Murali Krishna Reddy CT, Dr T Venkata Ravi KumarAssociate Professor, Department of General Surgery, Viswabarathi Medical College & General Hospital, RT Nagar, Penchikalapadu, Kurnool, India,Assistant Professor, Department of General Surgery, Viswabarathi Medical College & General Hospital, RT Nagar, Penchikalapadu, Kurnool, India,Assistant Professor, Department of General Surgery, Viswabarathi Medical College & General Hospital, RT Nagar, Penchikalapadu, Kurnool, India