309A STUDY OF SERUM PARAMETER CHANGES AND THE EFFECTS OF F. HEPATICA ON SHEEP LIVER FUNCTIONBased on the activity of specific enzymes and bilirubin in serum, the objective of this study was to assess the liver's functional capacity, as well as assess how F.hepatica affects the structures of the blood vessels in sheep livers and biliary tract. Blood samples and liver of 30 indigenous sheep of Pramenka breed were used. The animals were divided into two groups according to parasitological findings in their livers: control animals (n=17) and infected animals (n=13). Pathological changes were investigated and described in sheep liver naturally infected with F. hepatica, corrosion cast technique was used. When comparing sheep infected with controls, serum gamma-glutamyl transferase (GGT), total bilirubin (TBIL) and direct bilirubin (DBIL) levels were significantly higher in infected sheep groups (P<0.05). We found no significant difference between groups in the activity of aspartate aminotransferase (AST). An effect was found on the liver's vascular and biliary systems. Testing of tested parameters may provide an early diagnosis of sheep fasciolosis as well as a means of determining the effectiveness of an anti-helmintic therapy. As a consequence of mechanical and toxic effects of F. hepatica on sheep liver, corrosion casting technique is valuable for investigating pathological changes in vascular and biliary system of sheep liver, as well as neoangiogenesis of these structuresPradeep@gmail.comResearch1022020F.hepatica, Pramenka Breed, Anti-Helmintic Therapy, Sheep Liver Function.Dr Pradeep KumarAssistant Professor, Department of Physiology, Gouri Devi Institute of Medical Sciences and Hospital, Durgapur, India