302IMPACT OF TRANSIENTLY HIGH IOP DURING LASIK ON RETINAL FUNCTION AND STRUCTURE: OBSERVATIONAL STUDYLASIK surgery involves creating a corneal flap, followed by the ablation of corneal tissue to correct vision. During the procedure, transiently high intraocular pressures (IOP) may occur, potentially affecting retinal function and structure. In a prospective observational study, LASIK surgery patients were assessed pre- and postoperatively for visual acuity, contrast sensitivity, and color vision. Additionally, retinal ultrastructure was evaluated using optical coherence tomography (OCT) and electron microscopy techniques. The study revealed that LASIK surgery led to temporary elevations in IOP. Some patients experienced decreased contrast sensitivity and visual acuity postoperatively, along with abnormalities in color vision. OCT imaging showed thinning and disruption of retinal layers, particularly the outer layers. Electron microscopy revealed cytoplasmic vacuolization and mitochondrial abnormalities, indicating retinal stress. These findings suggest that transiently high IOP during LASIK surgery directly impacts retinal function and structure. The observed changes in visual acuity and contrast sensitivity underscore the importance of careful management during surgery, especially in patients with myopia. Further research is needed to better understand the mechanism behind LASIK-related transient high IOP and develop strategies to minimize its impact on retinal health.Kumar@gmail.comResearch1122021LASIK, Intraocular pressure (IOP), Retinal function, Retinal ultrastructure, Visual acuityDr. Anuj Kumar PathakAssociate Professor, Department of Pharmacology, Gouri Devi Institute of Medical Sciences & Hospital, Durgapur -713212, West Bengal, India