303ASSOCIATION BETWEEN SEVERE PSORIASIS AND CARDIOVASCULAR MORTALITY: INSIGHTS FROM A POPULATION-BASED STUDYPsoriasis, an inflammatory skin disorder, has been linked to cardiovascular diseases such as strokes, coronary artery disease, and myocardial infarction. This study utilized the General Practice Research Database to examine the risk of cardiovascular mortality in patients with severe psoriasis. A cohort of patients with severe psoriasis (n=14,3603) was compared to a control group of patients without psoriasis (n=14,330). The analysis revealed an independent association between severe psoriasis and cardiovascular mortality (HR 1.57, 95% CI 1.26, 1.96), even after adjusting for major cardiovascular risk factors such as age, gender, smoking, diabetes, hypertension, and hyperlipidemia. Despite controlling these factors, a significant number of patients with severe psoriasis still experienced fatal heart attacks. The study further observed that the risk of cardiovascular mortality increased with age, with individuals in their 40s exhibiting a higher risk ratio compared to those in their 60s. These findings underscore the importance of exploring the relationship between psoriasis management and cardiovascular risk in greater depth. Additionally, the study suggests that while psoriasis contributes to an elevated risk of cardiovascular disease, other factors may also play a role in this association. Further research has been warranted to better understand the mechanisms underlying this relationship and to develop effective strategies for managing both psoriasis and cardiovascular healthDeenadayalan@gmail.comResearch652016Psoriasis, Cardiovascular mortality, Inflammatory skin disease, Risk factors, General Practice Research Database.Dr. DeenadayalanAssistant Professor, Department of Community Medicine, Sri Lakshmi Narayana Institute of Medical Sciences & Hospital, Osudu, Puducherry - 605502, India