310INFECTIONS ASSOCIATED WITH CENTRAL LINES CAUSED BY STAPHYLOCOCCUS AUREUS MAY BE TREATED USING MINOCYCLINE-RIFAMPIN COATED CENTRAL VENOUS CATHETERSIf the patient has a septic infection, it may not always be possible to remove the central venous catheter (CVC) and insert a new one. The outcomes for patients who had their CVCs exchanged for MRI-coated CVCs with Within seven days take minocycline and rifampin of Staphylococcus aureus-associated CLABSI (SA-CLABSI). SA-CLABSI in two patients and removal of the CVC within seven days were matched with each case, as were two control patients with a CVC retention beyond seven days. The exchange of catheters was also modelled in vitro. SA-CLABSI was diagnosed in 40 patients. 8 patients Patients with retained CVCs included 68 patients who had their CVCs removed during a guidewire-guided conversion over M/R-CVC. A comparison was made between 8 patients with The CVCs of 8 patients were removed, while those of 8 patients were retained. Patients with CVCs removed or retained experienced similar clinical outcomes and relapse rates, compared with those whose CVC was exchanged over guidewire. Patients who retained their CVCs lost more life than those who lost their CVCs due to (p = 0.034) Exchange or removal. When catheter exchange over guidewire was compared to non-coated CVC in an in vitro model, catheter exchange over guidewire prevented the formation of biofilms completely. (p 0.0001). Exchange of the CVC over guidewire with MR-CVC is an alternative to removing the CVC and replacing it at a new site may lower the overall mortality rate in SA-CLABSI. There is a need for larger prospective randomized clinical trials]]>732017Staphylococcus Aureus, Central Vein Catheters, Infection Linked To Central LinesDr. Rakesh KumarAssistant Professor, Department of General Medicine, Bhaarath Medical College & Hospital, Selaiyur, Chennai – 600073