311COMPARISON OF TREATMENT MODALITIES FOR CUTANEOUS LEISHMANIASIS: INTRALESIONAL GLUCANTIME ALONE VERSUS COMBINATION THERAPY WITH FRACTIONAL CO2 LASER AND TRICHLOROACETIC ACIDCutaneous leishmaniasis, an endemic and contagious disease, poses treatment challenges despite the use of antimonial drugs as the primary therapeutic option. This study aimed to compare the efficacy of intralesional glucantime alone versus a combination therapy involving fractional carbon dioxide (CO2) laser, trichloroacetic acid (TCA), and glucantime for treating cutaneous leishmaniasis. Ninety patients were divided into three groups: intralesional glucantime alone, fractional laser plus glucantime, and fractional laser plus glucantime combined with topical TCA. The groups were assessed for changes in scar size and clinical improvements. The results revealed that the combination therapy groups showed faster improvement compared to glucantime alone, with significantly higher rates of complete improvement. In conclusion, intralesional glucantime combined with fractional CO2 laser is more effective in treating cutaneous leishmaniasis than glucantime alone.]]>822018 Cutaneous leishmaniasis, Glucantime therapy, Fractional CO2 laser, Combination therapy, Treatment efficacyDr. Esah RoyAssociate Professor, Department of Dermatology, Sri Lakshmi Narayana Institute of Medical Sciences & Hospital, Osudu, Agaram Village, Koodupakkam Post, Puducherry - 605502