31SCREENING OF INVIVO ANTIOXIDANT EFFECT OF ERYTHRINA VARIEGATA AGAINST CARBON TETRACHLORIDE (CCL4) INDUCED ERYTHROCYTE DAMAGE IN RATSEvaluation of invivo antioxidant effect of the ethanol extract of Erythrina variegata (EEEV) was assessed in rats with carbon tetrachloride (CCl4) induced erythrocyte damage. Alternate days of two weeks, simultaneous administration of the EEEV (200 & 400 mg/kg body weight/day, i.p) with carbon tetrachloride (1ml/kg of body weight) to rats for protected the loss of functional integrity and membrane lipid alteration in red blood cells induced by oxidative stress. EEEV suppressed the accumulation of lipid peroxidation in the plasma as well as maintained the activities of antioxidant enzymes such as superoxide dismutase (SOD) and catalase. The EEEV further had the ability to decrease the membrane fluidity induced by CCl4. The present investigation confirmed the antioxidant effect of the ethanol extract of Erythrina variegata (EEEV) by protect the erythrocyte against CCl4 induced oxidative stresskarunamkswamy@gmail.comResearch322013Antioxidant enzymes,Carbon tetrachloride,Erythrina variegata,Erythrocyte DamageKarunambigai M,B. VenkateswarluDepartment of Statistics, Madawalabu University, Bale Robe, Ethiopia,Faculty of Biochemistry, College of Health Sciences, Madawalabu University, Bale Robe, Ethiopia.